Agent-Based Modeling of Herbal Compound Treatment for Allergic Inflammation in Asthma

Articles in Press

Document Type : Research Paper

Authors

1 Department of Electrical Engineering, Faculty of Engineering, University of Zanjan, Zanjan, Iran

2 Department of Computer Engineering, Faculty of Engineering, University of Zanjan, Zanjan, Iran

Abstract

Asthma is a complex disease characterized by chronic airway inflammation and immune system dysfunction. In recent decades, researchers have conducted extensive studies on plants with anti-allergic and anti-asthmatic effects. In this study, an agent-based model is presented to simulate the interactions between immune cells and lung tissue during asthmatic inflammation. For the first time, herbal drug treatments for asthma have been incorporated into the model based on experimental data and previous modeling studies. The model parameters were determined using experimental data from laboratory studies on asthma treatment with herbal compounds. The model's outputs align well with experimental data and effectively replicate them. Using this model, we have investigated several phenomena related to asthma treatment: (1) Determining the optimal day to initiate treatment, (2) Evaluating the contribution of each inflammatory pathway to lung health, (3) Assessing the effect of anti-inflammatory pathways on lung tissue health, (4) Performing global sensitivity analysis and identifying key parameters in the model, (5) Examining how removing drug effects on pro-inflammatory and anti-inflammatory pathways influences the model's output. The findings of this study validate existing experimental research and provide valuable insights into understanding asthma pathogenesis and potential therapeutic approaches using herbal medicines.

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Main Subjects

Journal of Modeling in Engineering

Articles in Press, Accepted Manuscript
Available Online from 05 October 2025

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History

  • Receive Date: 29 June 2024
  • Revise Date: 04 July 2025
  • Accept Date: 26 August 2025

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