مدل سازی فرایند تولید نانو ومیکرو ذرات نابومتن با فرایند انبساط ناگهانی محلول های فوق بحرانی

نویسندگان

دانشگاه سمنان

چکیده

در این مقاله تولید ذرات ریزساختار نابومتن با استفاده از فرایند انبساط ناگهانی محلول های فوق بحرانی (RESS) مدل شده است. برای مدل سازی فرایند RESS از یک مدل ریاضی استفاده شده و با استفاده از این مدل، متوسط اندازه ذرات و توزیع اندازه ذرات نابومتن تخمین زده شده است. همچنین با استفاده از مدل ارائه شده، اثر شرایط عملیاتی موثر بر فرایند RESS از جمله فشار و دمای انبساط، فشار و دمای استخراج و فاصله اسپری بر روی مشخصات محصول تولید شده بررسی شده است. نتایج محاسبات نشان می دهند که تطابق خوبی میان نتایج تجربی و داده های محاسباتی وجود دارد.

کلیدواژه‌ها


عنوان مقاله [English]

MATHEMATICAL MODELING FOR RAPID EXPANSION OF SUPERCRITICAL SOLUTION TO PRODUCE NANO AND MICRO NABUTEMON PARTICLES

نویسندگان [English]

  • hadi Baseri
  • lotfollahi Lotfollahi
semnan university
چکیده [English]

A new model is proposed for production of fine particles of Nabutemon by rapid expansion of supercritical solutions (RESS). A mathematical model is used for prediction of particle size and particle size distribution of RESS produced particles. In this model the effect of various operating parameters such as pressure and temperature of extraction and temperature and pressure of expansion on the characteristics of products were studied. The calculation results showed good agreement between the calculation results and the experimental data for Nabutemon particles.

کلیدواژه‌ها [English]

  • Supercritical carbon dioxide
  • Rapid expansion of supercritical solutions
  • Micro-particles
  • Nabutemon
 
[1] Imanaka, N., Kohler, J., Masui, T., Adachi, G.Y., Taguchi, E., Mori, H. (2000). Inclusion of nanometer-size Al2O3 particles in a crystalline (Sc, Lu)(2)(WO4)(3) matrix, Journal of American Ceramic Society, 83, 427-429.
[2] Lines, M.G. (2008). Nanomaterials for practical functional uses, Journal of Alloys and Compounds, 449, 242-245.
[3] Roco, M.C. (1999). Nanoparticles and nanotechnology research, Journal of Nanoparticle Research, 1, 1-6.
[4] Kikic, I., Lora, M. (1997). A thermodynamic analysis of three-phase equilibria in binary and ternary systems for applications in rapid expansion of a supercritical solution (RESS), particles from gas-saturated solutions(PGSS), and supercritical antisolvent (SAS), Industrial Engineering Chemistry Research, 36, 5507-5515.
[5] Türk, M., Bolten, D. (2010). Formation of submicron poorly water-soluble drugs by rapid expansion of supercritical solution (RESS): Results for Naproxen, Journal of Supercritical Fluids, 55, 778–785.
[6] Hezave, A.Z., Esmaeilzadeh, F. (2010). Crystallization of micro particles of sulindac using rapid expansion of supercritical solution, Journal of Crystal Growth, 312, 3373–3383.
[7] Hezave, A.Z., Esmaeilzadeh, F. (2010). Investigation of the rapid expansion of supercritical solution parameters effects on size and morphology of cephalexin particles, Journal of Aerosol Science, 41, 1090–1112.
[8] Vemavarapu, C., Mollan, M.J., Needham, T.E. (2009). Comprecipitation of pharmaceutical actives and their structurally related by the RESS process, Powder Technology, 189, 444-453.
[9] Lee, A.K., Shine, A.D. (1992). Morphology of polymers precipitated from a supercritical solvent, AIChE Journal, 38-5, 742-752.
[10] weber, M., Russell, L.M., Debenedetti, P.G. (2002). Mathematical modeling of nucleation and growth of particles formed by the rapid expansion of a supercritical solution under subsonic conditions, Journal of Supercritical Fluids, 23, 65-80.
[11] Helfgen, B., Hils, P., Holzknecht, Ch., Turk, M., Schaber, K. (2001). simulation of particle formation during the rapid expansion of supercritical solutions, Journal of Aerosol Science, 32, 295-319.
[12] Debenedetti, P.G. (1990). Homogeneous nucleation in supercritical fluids, AIChE Journal, 36-9, 1289-1298.
[13] Weber, M., Thies, M.C. (2007). A simplified and generalized model for the rapid expansion of supercritical solutions, Journal of Supercritical Fluids, 40, 402-419.
[14] Ghoreishi, S.M., Komeili, S. (2009). Modeling of fluorinated tetraphenylporphyrin nanoparticles size design via rapid expansion of supercritical solution, Journal of Supercritical Fluids, 50, 183-192.
[15] Helfgen, B., Turk, M., Schaber, K. (2003). Hydrodynamic and aerosol modeling of rapid expansion of supercritical solutions (RESS-process), Journal of Supercritical Fluids, 26, 225-242.
[16] Kaibi, K., Tenaud, C., Subra, P., Garrabos, Y. (1996). Numerical simulation of rapid expansion of supercritical fluids, European Journal of Mechanics B/Fluids, 15(4), 569-596.
[17] Su, C.S., Tang, M., Chen, Y.P. (2009). Micronization of nabumetone using the rapid expansion of supercritical solution (RESS) process, Journal of Supercritical Fluids, 50, 69–76.
[18] H.-H. Tung, E. L. Paul, M. Midler, J. A. McCauley, Crystallization of Organic Compounds An Industrial Perspective, John Wiley & Sons, Inc., Hoboken, New Jersey, (2009).
[19] White, F.M. (2003). Fluid Mechanics, fifth ed., McGraw Hill, New York.
[20] Prausnitz, J.M., Lichtenthaler, R.N., de Azevedo, E.G. (1999). Molecular Thermodynamics of Fluid-Phase Equilimria, Third ed., Prentice Hall PTR, New Jersey.
[21] Angus, S., Armstrong, B., de Reuck, K.M. (1976). International Thermodynamic Tables of the Fluid State—Carbon Dioxide, Pergamon Press, London.
[22] Walas, S.M. (1985). Phase Equilibria in Chemical Engineering, Butterworth, MA.
[23] Sun, Y.P. (2002). Supercritical Fluid Technology in Materials Science and engineering, Marcel Dekker, New York.
[24] To, D., Dave, R. (2009). Deagglomeration of Nanoparticle Aggregates via Rapid Expansion of Supercritical or High-Pressure Suspensions, AIChE Journal, 55(11), 2807-2826.
[25] Li, J., Matos, H.A., de Azevedo, E.G. (2004). Two-phase homogeneous model for particle formation from gas-saturated solution processes, Journal of Supercritical Fluids, 32, 275-286.
[26] Hirunsit, P., Huang, Z., Srinophakun, T., Charoenchaitrakool, M., Kawi, S. (2005). Particle formation of ibuprofen–supercritical CO2 system from rapid expansion of supercritical solutions (RESS): A mathematical model, Powder Technology, 154, 83 – 94.
[27] Kim, D.H., Gautam, M., Gera, D. (2002). Modeling Nucleation and Coagulation Models in the Formation of Particulate Matter inside a Turbulent Exhaust Plume of a Diesel Engine, Journal of Colloid and Interface Science, 249, 96-103.
[28] Qumar, S., Warnecke, G., Elsner, M.P. (2009). On the solution of population balances for nucleation, growth, aggregation and breakage processes, Chemical engineering Science 64, 2088-2095.
[29] Su, C.S., Chen, Y.P. (2008). Measurement and correlation for the solid solubility of nonsteroidal anti-inflammatory drugs (NSAIDs) in supercritical carbon dioxide, Journal of Supercritical Fluids, 43, 438–446.
[30] Seinfeld, J.H., Pandis, S. (1998). Atmospheric Chemistry and Physics: From Air Pollution to Climate Change, John Wiley and Sons, New York.