نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه برق، دانشکده مهندسی، دانشگاه زنجان، زنجان، ایران
2 گروه برق، دانشکده مهندسی، دانشگاه زنجان
3 گروه کامپیوتر، دانشکده مهندسی، دانشگاه زنجان
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Asthma is a complex disease characterized by chronic airway inflammation and immune system dysfunction. In recent decades, researchers have conducted extensive studies on plants with anti-allergic and anti-asthmatic effects. In this study, an agent-based model is presented to simulate the interactions between immune cells and lung tissue during asthmatic inflammation. For the first time, herbal drug treatments for asthma have been incorporated into the model based on experimental data and previous modeling studies. The model parameters were determined using experimental data from laboratory studies on asthma treatment with herbal compounds. The model's outputs align well with experimental data and effectively replicate them. Using this model, we have investigated several phenomena related to asthma treatment: (1) Determining the optimal day to initiate treatment, (2) Evaluating the contribution of each inflammatory pathway to lung health, (3) Assessing the effect of anti-inflammatory pathways on lung tissue health, (4) Performing global sensitivity analysis and identifying key parameters in the model, (5) Examining how removing drug effects on pro-inflammatory and anti-inflammatory pathways influences the model's output. The findings of this study validate existing experimental research and provide valuable insights into understanding asthma pathogenesis and potential therapeutic approaches using herbal medicines.
کلیدواژهها [English]
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