مدل‌سازی اثرCEST از طریق تشدید مغناطیسی برای تعیین همزمان نرخ تبادل شیمیایی و غلظت آمین و آمید در بدن انسان

نوع مقاله : مقاله پژوهشی

نویسنده

گروه مهندسی پزشکی، دانشگاه صنعتی همدان، همدان، ایران

چکیده

انتقال اشباع منجر به جابجایی هیدروژن‌های آب و مولکول‌های بافت‌های بدن از طریق اعمال پالس اشباع الکترومغناطیسی به رشته پالس تصویربرداری اسکنر تشدید مغناطیسی می‌شود. اثر CEST حاصل از تبادل مابین عامل‌های کنتراست درونی یا بیرونی با آب موجود در بدن، یکی از زیربخش‌های فرآیندهای تبادل شیمیایی محسوب می‌شود. اثر CEST به عواملی همچون زمان‌های استراحت، نرخ تبادل شیمیایی، غلظت عامل کنتراست و ویژگی‌های پالس اشباع الکترومغناطیسی بستگی دارد. از این عوامل می‌توان به اطلاعاتی از نحوه تعامل شیمیایی، آنزیم‌ها، متابولیت‌ها، یون‌های فلزی، pH، مصرف گلوکز و دیگر شرایط بالینی دست یافت. این مقاله روابطی تحلیلی برای تعیین نرخ تبادل شیمیایی و غلظت عامل کنتراست از طریق مدل‌سازی اثر CEST به عنوان تابع هدف با استفاده از نمودار امگا تعیین می‌کند.علاوه بر آن با محاسبه دامنه بهینه پالس الکترومغناطیسی مستطیلی از طریق بیشینه‌سازی تابع هدف محدب‌گونه پیشنهادی اثرCEST، مجددا نرخ تبادل شیمیایی و غلظت عامل کنتراست مورد ارزیابی قرار می‌گیرد. ارزیابی نتایج دو راهکار پیشنهادی با استفاده از داده‌های پارامتری دوحوضچه‌ای آمید-آب و آمین-آب از طریق مقایسه با دو بیان دیگر از اثر CEST که مورد استناد مطالعات متعددی بوده نیز انجام گرفته است. نمودارهای امگا حاصله از مدل‌سازی پیشنهادی اثرCEST ، بهترین انطباق در تعیین نرخ تبادل و غلظت را برای ترکیب آب-آمین بر اساس کمترین درصد خطای نسبی، حدودا 5/0% و 8/4% به ترتیب بوده است. از طرفی بر مبنای روش تعیین دامنه بهینه، بهترین تطابق در تخمین نرخ تبادل و غلظت به ترتیب با دقت 91% و 100%، در آمیدها حاصل شده است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Modeling of the Cest Effect for Determining Chemical Exchange Rate and Concentration of Amine and Amide in the Human Through Magnetic Resonance Simultaneously

نویسنده [English]

  • Mohammad Reza Rezaeian
Biomedical Engineering Department, Hamedan University of Technology, Hamedan, Iran
چکیده [English]

The saturation transfer  leads to exchange between hydrogens of water and hydrogens of molecules tissue  by applying radio frequency (RF) saturation pulse to the sequence of the magnetic resonance imaging. The CEST effect, which occurs between water protons and exogeneous or endogeneous contrast agents, is considered one of the important subsections of the set of chemical exchange saturation transfer processes. The CEST effect mainly depends on relaxation times, chemical exchange rate, contrast agent concentration and characteristics of the RF saturation pulse. Based on these factors, can be obtained important information from chemical interactions, enzymes, metabolites, metal ions, pH, glucose consumption and other clinical conditions. In this article, chemical exchange rate and contrast agent concentration are determined quantitatively through the Omega-plot by computing the CEST effect.In addition, the chemical exchange rate and concentration are determined through the optimal amplitude RF rectangular at the maximum of the proposed CEST effect as goal function.The evaluation of two proposed approaches has been done using two sets of parametric data, amide-water and amine-water, and two other definitions of the CEST as a comparison with the reference definition.The Omega-plots are calculated for each parametric data based on different definitions of CEST effect, the good agreement is for water-amine through minimum relative sum square error, about 0.5% and 4.8% compared to the reference definition. On the other hand based on optimizing reference definition of the CEST, the best agreement is for water-amid, through estimating the chemical exchange rate and contrast agent concentration about 91% and 100% respectively.

کلیدواژه‌ها [English]

  • Saturation transfer
  • Contrast agent
  • CEST effect modeling
  • Chemical exchange rate

مراجع

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مدل سازی در مهندسی
دوره 23، شماره ویژه 81
جشن پنجاهمین سالگرد تاسیس دانشگاه سمنان- در حال تکمیل شدن
تیر 1404
صفحه 221-233

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  • تاریخ دریافت: 14 اردیبهشت 1403
  • تاریخ بازنگری: 08 آبان 1403
  • تاریخ پذیرش: 12 آبان 1403

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